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Results of metabolic profiling have pointed to the presence of a chronic catabolic state associated with sub-health. In a relatively large study, depletion of excreted amino acids in CFS was demonstrated in comparison to non-fatigued controls. Altered amino acid levels have been demonstrated by the current research team in association with sub-health conditions including chronic fatigue and fatigue in radiotherapy breast cancer patients. Research into the underlying causes of CFS and CRF has revealed the presence of altered amino acid homeostasis in these conditions. There is an increasing need for scientifically validated therapies which can effectively and simply treat the symptoms of sub-heath including fatigue. The aetiology of both CFS and CRF remain largely unknown and no effective treatment strategies have yet been agreed upon. In the past, interest in the treatment of fatigue has focussed on the more severe fatigue states of cancer-related fatigue (CRF) and CFS. The more severe cases of sub-health may present as conditions such as chronic fatigue syndrome (CFS) and fibromyalgia. Sub-health is usually indicated by the presence of lowered energy levels, loss of vitality, altered sleeping patterns and an increased incidence of viral infections all occurring in the absence of a defined disease diagnosis. In contrast, sub-health has been described as a chronic condition of unexplained deteriorated physiological function which falls between health and illness. The World Health Organisation defines health as “a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity”. Further product development may yield additional options for those patients susceptible to fructooligosaccharide. The product could provide an effective tool for the management of unexplained fatigue and symptoms of sub-health.
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The results indicated that Fatigue Reviva™ was palatable and that 65% of the study group reported that they felt the product had improved their health. Discriminant function analysis of the urinary amino acid data revealed significant differences between the pre- and post-supplement urine excretion profiles. Analysis of urinary amino acids revealed significant alterations in the relative abundances of a number of amino acids after supplementation including an increase in valine, isoleucine and glutamic acid and reduced levels of glutamine and ornithine. A subgroup of participants reported gastrointestinal symptoms which were attributed to the supplement and which were believed to result from the component fructooligosaccharide. When asked whether they thought that the supplement had improved their health, 65% of participants responded positively. Following amino acid supplementation the total Chalder fatigue score improved significantly (mean ± SEM, 12.5 ± 0.9 versus 10.0 ± 1.0, P<0.03). Comparisons were then made between pre- and post-supplement general health symptoms and urinary amino acid profiles. Each participant took an amino acid based dietary supplement (Fatigue Reviva™) daily for 30 days.
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Males reporting symptoms of sub-health were recruited on the basis of being free from any significant medical or psychological condition. This initial study sets out to provide an initial appraisal of product palatability and to gather pilot evidence for efficacy. Complex formulations of amino acids present significant challenges due to solubility and taste constraints. A new dietary supplement, Fatigue Reviva™, has been recently developed to address issues related to amino acid depletion following illness or in conditions of sub-health where altered amino acid homeostasis has been associated with fatigue.